Clinical Trials

Discover our comprehensive approach to conducting clinical trials for Oral Health, Personal Care and Premium Skin Health products and devices to give confidence in their efficacy.

Colgate is the oldest, most committed, and trusted consumer products company. With over 200 years of experience, we have the pleasure of serving hundreds of millions of people worldwide. We conduct over 200 clinical trials each year to advance technologies that can address changing consumer needs throughout the world.

Oral Health Studies

Clinical studies help us understand the true health benefits of our Oral Care products and help us to develop new products to address emerging Oral Health conditions. Our Oral Health clinical investigations have studied the benefit of products designed to improve tooth whitening, gingival health, tooth sensitivity and plaque removal.The studies also help us to understand the biological processes that lead to oral disease so that we can create better therapies to prevent and treat them. As a result, we are able to develop groundbreaking products using advanced technologies which deliver remarkable results including Colgate Total and Optic White toothpaste. We are currently conducting studies related to arginine. Click here to learn more.

Colgate’s Research on Oral Health

Learn more about Colgate’s oral health research, published in nationally and globally acclaimed journals including the Journal of Oral Microbiology and the Journal of the American Dental Association.

• A Dual Zinc plus Arginine formulation attenuates the pathogenic properties of Porphyromonas gingivalis and protects gingival keratinocyte barrier function in an in vitro model.

• Antiplaque and antigingivitis efficacy of cetylpyridinium chloride with zinc lactate compared with essential oil mouthrinses: Randomized clinical trial.

Personal Care Studies

Our Personal Care clinical studies assess the benefits of products developed to clean, moisturize, freshen, maintain an even skin tone, and provide odor and wetness protection. Clinical evaluations are conducted by trained professionals to ensure all Colgate’s brands and products deliver on their promise of performance. The studies deepen our understanding of how to support biological systems that control skin hydration and moisturization, balance the skin’s microbiome or how to control underarm wetness and odor.

The learnings from these studies are used to develop and improve the performance of many products including Irish Spring soap and shower gel, Speed Stick, and Lady Speed Stick antiperspirant/deodorant. We take great care to ensure all our products perform safely and effectively.

Premium Skin Health Studies

Our Premium Skin Health studies are critical to the development of high performance products and regimens.  They have confirmed the delivery and enhanced penetration of active ingredients such as Vitamin C and Vitamin E. The learning from these studies are used to develop and optimize the performance of many products including those from PCA Skin and EltaMD.

Colgate’s Research on Premium Skin Health

Learn more about Colgate’s premium skin health, published in nationally and globally acclaimed journals including Journal of Drugs in Dermatology and Journal of Cosmetic Dermatology. See two examples below.

• Efficacy and Tolerability of a Skin Brightening/Anti-Aging Cosmeceutical Containing Retinol 0.5%, Niacinamide, Hexylresorcinol, and Resveratrol (Intensive Brightening Treatment-0.5% pure retinol night)

• A novel skin brightening technology (C&E Advanced-with Hexylresorcinol and Silymarin)